(1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones

US4460581A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Kurt Schromm · Ingelheim am Rhein, DE
• Anton Mentrup · Mainz, DE
• Ernst-Otto Renth · Ingelheim am Rhein, DE
• Armin Fugner · Gau-Algesheim, DE

Key dates

• Filing date: Oct 12, 1982
• Grant date: Jul 17, 1984
• Expiry date: Oct 12, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A is a single bond, ##STR2## R.sub.1 is --OH, --0--acyl, chlorine or hydrogen; R.sub.2 is hydrogen, methyl or ethyl; PA1 R.sub.3 is ##STR3## m is 2, 3 or 4; n is 1, 2 or 3; PA1 R.sub.4 is hydrogen or lower alkyl; PA1 R.sub.5 is hydrogen, lower alkyl or, when R.sub.4 is hydrogen, also phenyl; PA1 R.sub.6, R.sub.7 and R.sub.8 are each hydrogen or methyl; PA1 R.sub.9 is hydrogen, --Ar, --OAr or --NH--CO--Ar; PA1 Ar is ##STR4## R.sub.10, R.sub.11 and R.sub.12 which may be identical to or different from each other, are each hydrogen, hydroxyl, methyl, methoxy, halogen, methylenedioxy, --NH--R.sub.13 or --CONH.sub.2 ; and PA1 R.sub.13 is hydrogen, acyl or lower alkylsulfonyl; and non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as their salts are useful for the treatment of asthma, bronchitis, urticaria, conjunctivities, hay fever, colds and cardiovascular disorders, and for relaxation of the uterine musculature.