Oligomers of compounds of the muramyl-peptide type and medicaments containing them

US4461761A · kind A · utility

Assignee

• Agence Nationale de Valorisation de la Recherche · FR

Inventors

• Pierre Lefrancier · Les Ulis, FR
• Monique Parant · Paris, FR
• Francoise Audibert · Neuilly-sur-Seine, FR
• Edgar Sache · Les Ulis, FR
• Louis Chedid · Paris, FR
• Jean Choay · Paris, FR
• Edgar Lederer · Sceaux, FR

Key dates

• Filing date: Aug 23, 1982
• Grant date: Jul 24, 1984
• Expiry date: Aug 23, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K9/005
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the peptide type including at least two aminoacyl residues, the first being selected from among: L-alanyl, L-arginyl, L-asparagyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-methionyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-valyl, and the second aminoacyl is D-glutamyl or D-isoglutaminyl. They are useful for their immunoregulator properties and for the preparation of pharmaceutical compositions.