"Oximes of 3'""-dehydrocardenolide tridigitoxosides"

US4461763A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang Schaumann · Heidelberg, DE
• Fritz Kaiser · Lampertheim, DE
• Wolfgang Voigtlander · Viernheim, DE
• Edgar Hoyer · Mannheim, DE
• Peter Neubert · Weinheim, DE

Key dates

• Filing date: Nov 5, 1982
• Grant date: Jul 24, 1984
• Expiry date: Nov 5, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R.sub.1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R.sub.2 is a hydrogen atom or a lower acyl or alkyl radical and R.sub.3 represents two hydrogen atoms, the group ##STR2## or the oximino group .dbd.NOR.sub.1, wherein R.sub.1 has the above-given meaning. The present invention also provides a process for the preparation of these oximes, as well as pharmaceutical compostions containing them which are useful for the treatment of cardiac insufficiency.