Nitrogen bridgehead compounds having anti-allergic effect
US4461769A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1979 |
| Grant date | Jul 24, 1984 |
| Priority date | — |
| Expiry date | Sep 19, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosed wherein PA1 R is hydrogen or lower alkyl PA1 R.sup.1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; or PA1 R and R.sup.1 together form a group of the formula --(CH.dbd.CH).sub.2 -- and in this case the broken line represents a further C--C bond, while in all other cases there is a single bond between positions 6 and 7; PA1 R.sup.2 is hydrogen, lower alkyl or hydroxy; PA1 R.sup.3 is hydrogen, lower alkyl, aryl, lower alkanoyl, carboxyl or a carboxyl acid derivative or a group of the formula --(CH.sub.2)m--COOH or a derivative thereof formed in the carboxylic group; PA1 n=1-3; PA1 R.sup.4 is hydrogen, lower alkyl which can be substituted by hydroxy or carboxy; trifluoromethyl, substituted or unsubstituted aryl, phenyl-lower alkyl or substituted or an unsubstituted heterocyclic group; PA1 R.sup.5 is hydrogen, lower alkanoyl, substituted or unsubstituted benzoyl or heteroaryl; or PA1 R.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a piperidino, pyrrolidino or morpholino ring;…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.