Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US4464529A · kind A · utility
10Cited by
2References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 24, 1983 |
| Grant date | Aug 7, 1984 |
| Priority date | — |
| Expiry date | May 24, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A group of new daunorubicin and doxorubicin derivatives is disclosed. These materials have the formula ##STR1## wherein R is CO--CH.sub.3 or CHOH--CH.sub.3 in the case of daunorubicin derivatives or CO--CH.sub.2 OH or CHOH--CH.sub.2 OH in the case of doxorubicin derivatives; X is O or NH; and A is either a cyano group (CN) or a hydrogen, subject to the limitation that when X is O, A must be a cyano group. When A is hydrogen, these compounds can exist as acid addition salts, as well. Derivatives of these compounds are disclosed as well.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.