Prothrombin complex concentrates, preparation and application thereof
US4465623A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 17, 1983 |
| Grant date | Aug 14, 1984 |
| Priority date | — |
| Expiry date | Mar 17, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/831
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Procedure for the preparation of a concentrate of prothrombinogenic compound. This procedure, in which, starting from a source of prothrombinogenic compound, an adsorption is followed by an elution, is characterized by the fact that a source of prothrombinogenic compound and a source of antithrombin III (or AT III) is placed in contact with an adsorbing agent capable of adsorbing both the prothrombinogenic compound and antithrombin III, and that the foregoing occurs in the presence of heparin, at least during the elution stage, and that elution is carried out with an elution agent capable of eluting the prothrombinogenic compound, the AT III and heparin at the same time. Application of the product obtained, notably to the treatment of blood coagulation difficulties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.