Antiinflammatory and antiallergic imidazole derivatives

US4466976A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Walter Klose · Berlin, DE
• Irmgard Boettcher · Lahr (Eifel), DE

Key dates

• Filing date: Oct 13, 1982
• Grant date: Aug 21, 1984
• Expiry date: Oct 13, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Imidazole derivatives of Formula I ##STR1## wherein AR.sub.1 and AR.sub.2 each independently represent phenyl optionally substituted by halogen atoms, alkyl groups, or alkoxy groups, PA0 R.sub.1 is pyrrolyl, indolyl, imidazolyl, or thiazolyl, all of which are optionally substituted by lower alkyl, free or esterified carboxy or carboxyalkyl groups, benzyl, or benezenesulfonyl; and R.sub.2 is hydrogen, lower alkyl, haloalkyl, or a methylene, dimethylene, trimethylene, or tetramethylene group linked to the nitrogen atom of R.sub.1, PA0 and the physiologically acceptable salts thereof with acids, and when R.sub.1 is substituted by carboxy, also the physiologically acceptable salts thereof with bases, PA0 are pharmacologically effective compounds, e.g., as antiinflammatories.