3-Aralkyloxy-2,3-dihydro-2-(triazolymethyl)benzo(b)thiophenes
US4468404A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 29, 1982 |
| Grant date | Aug 28, 1984 |
| Priority date | — |
| Expiry date | Jul 29, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D335/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Aralkyloxy-2,3-dihydro-2-(triazolylmethyl)benzo(b)thiophenes and related derivatives having antifungal, antibacterial, and antiprotozoal activity are prepared by the reaction of the corresponding 2,3-dihydro-3-hydroxy-2-(triazolylmethyl)benzo(b)thiophene or related derivative and an aralkyl halide. Preferred compounds are those where the aralkyl function is a hetercyclic aromatic, particularly 2-chloro-3-thenyl, and where the benzene nucleus is substituted by chlorine or fluorine. Pharmaceutical formulations comprising compounds of this invention are described, as well as the method for their use in treating microbial infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.