Microprocessor system for quantitative chromatographic data analysis
US4468742A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 17, 1981 |
| Grant date | Aug 28, 1984 |
| Priority date | — |
| Expiry date | Mar 17, 2001 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06F2218/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Quantitative chromatography is widely used in many fields to measure the amount of a compound present in a mixture. A series of Gaussian-like peaks are generated as output, and the size is conventionally measured by peak area or peak height determinations. The microprocessor-based analysis system of the present invention is designed to "learn" the characteristics of a set of chromatographic peaks. Retention time and peak width parameters are used to detect and measure selected peaks by a convolution procedure based on a matched filter. The filter is applied to peaks in the neighborhood of selecting peak times which have a shape closely resembling that of a control sample. The system is built around a microprocessor with a wide dynamic range analog-to-digital conversion input stage. Operator interaction with the programs and the printing of output results is facilitated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.