Di- or trisubstituted xanthines with neuroleptic properties and composition

US4469698A · kind A · utility

Assignee

• Societe d'Assistance Technique pour Produits Nestle S.A. · CH

Inventors

• Georges Philippossian · Lausanne, CH
• Marc Enslen · Yverdon-les-Bains, CH

Key dates

• Filing date: Feb 28, 1983
• Grant date: Sep 4, 1984
• Expiry date: Feb 28, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to xanthines corresponding to the formula ##STR1## and physiologically acceptable salts thereof, in which R.sub.1 represents C.sub.2 -C.sub.4 -alkyl, C.sub.3 -C.sub.4 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.3 -alkenyl) or CH.sub.2 -(C.sub.3 -isoalkenyl); PA0 R.sub.3 represents C.sub.3 -C.sub.5 -alkyl, C.sub.3 -C.sub.5 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.4 -alkenyl) or CH.sub.2 -(C.sub.3 -C.sub.4 -isoalkenyl); PA0 R.sub.8 represents H, methyl or ethyl; with the proviso that PA0 (1) when R.sub.8 represents H, R.sub.1 is allyl and PA0 (2) R.sub.1 and R.sub.3 cannot both represent butyl or allyl at the same time. The compounds show non-specific or anxiolytic sedative activity.