Nontoxic, immunologically crossreactive toxin A protein from Pseudomonas aeruginosa

US4470924A · kind A · utility

Inventors

• Barbara M. Iglewski · Portland, US
• Stanley J. Cryz · Bolligen, CH

Key dates

• Filing date: Dec 30, 1981
• Grant date: Sep 11, 1984
• Expiry date: Dec 30, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nontoxic, immunologically crossreactive toxin A protein produced by a PAO-PR1 mutant strain of Pseudomonas aeruginosa. The protein, in activated form, has substantially no adenosine diphosphate-ribosylating activity, and is nontoxic to cells known to be susceptible to the parent PAO-1 strain of Pseudomonas aeruginosa from which strain PAO-PR1 was derived. The nontoxic toxin A protein is immunologically indistinguishable from, and has a molecular weight similar to, native toxin A protein produced by the PAO-1 strain.