Certain hydrolysis or reductive cleavage reaction involving 4h-pyrano(3,2-g) quinoline-2,8-dicarboxylic acid derivatives
US4471119A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 27, 1982 |
| Grant date | Sep 11, 1984 |
| Priority date | — |
| Expiry date | Sep 27, 2002 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is described a process for the production of a compound of formula I, ##STR1## in which R is hydrogen or alkyl Cl to 6, and R.sub.5 and R.sub.10, which may be the same or different, are each hydrogen or alkyl Cl to 6, PA1 or a pharmaceutically acceptable derivative thereof, PA1 which comprises removal of an activating group from a compound of formula II, ##STR2## or a suitable derivative thereof, in which R, R.sub.5 and R.sub.10 are as defined above, and PA1 X represents an activating group, PA1 and if desired or necessary converting the resulting compound of formula I to a pharmaceutically acceptable derivative thereof, or vice versa. There is also described a process for the production of a compound of formula II in which R is hydrogen, or a suitable derivative thereof, which comprises reaction of a compound of formula III, ##STR3## or a suitable derivative thereof, in which R.sub.5 and R.sub.10 are as defined above, with a compound of formula IV, EQU X--N.dbd.C.dbd.O IV in which X is as defined above.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.