5.beta.-Hydroxy-.DELTA..sup.6 -steroids and process for the preparation thereof
US4472310A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 11, 1982 |
| Grant date | Sep 18, 1984 |
| Priority date | — |
| Expiry date | Mar 11, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The disclosure concerns 5.beta.-hydroxy-.DELTA..sup.6 -steroids of the general formula ##STR1## wherein R.sup.1 is hydrogen, acyl, lower alkyl, or the tetrahydropyranyl residue and PA1 R.sup.2, R.sup.3 individually are respectively hydrogen or jointly are methylene and PA1 X stands for oxygen, the groupings ##STR2## (wherein R.sup.4 means hydrogen or acyl) and ##STR3## (wherein R.sup.5 means hydrogen or lower alkyl) and a process for the preparation thereof by reacting corresponding 7.alpha.-chloro-5.beta.,6.beta.-epoxy steroids in an inert solvent with metallic zinc in a lower aliphatic carboxylic acid or dilute mineral acid at temperatures of between room temperature and 100.degree. C., preferably at 40.degree.-70.degree. C. The compounds producible by this method are intermediates for the preparation of 3-keto-.DELTA..sup.4 -6.beta.,7.beta.-methylene steroids constituting pharmacologically valuable compounds, for example aldosterone antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.