Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis
US4472430A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 1982 |
| Grant date | Sep 18, 1984 |
| Priority date | — |
| Expiry date | Jun 28, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2,NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.