Diphosphonic acid derivatives and pharmaceutical preparations containing them

US4473560A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Clemens Rufer
• Irmgard Boettcher · Lahr (Eifel), DE

Key dates

• Filing date: Jan 27, 1983
• Grant date: Sep 25, 1984
• Expiry date: Jan 27, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/655345
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein n is 0, 1, or 2; PA1 R.sup.1 is hydrogen or alkyl of 1-4 carbon atoms; PA1 R.sup.2 is hydrogen, an alkali metal atom, an alkaline earth metal atom, or alkyl of 1-4 carbon atoms; and PA1 Ar is phenyl; phenyl substituted by fluorine, chlorine, alkyl of 1-4 carbon atoms, or alkoxy of 1-4 carbon atoms; naphthyl; biphenyl; or thienyl; PA1 or when R.sup.2 is H, a physiologically acceptable salt thereof with an organic base PA1 have valuable antiinflammatory properties.