Preparation of cyclic-keto-acids

US4473706A · kind A · utility

Assignee

• Ethyl Corporation · US

Inventors

• John Y. Lee · Baton Rouge, US
• Thomas Walter · Penzberg, DE

Key dates

• Filing date: Aug 6, 1982
• Grant date: Sep 25, 1984
• Expiry date: Aug 6, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Cyclic-keto-acids of the general formula: ##STR1## wherein R is hydrogen or a monovalent alkyl radical which can be either straight chain or branched having from 1 to about 20 carbon atoms and X=1, 3, or 4, are prepared by reacting a functionalized 1-bromoalkane of the formula: ##STR2## wherein R and X are as defined above and Y is a leaving group, preferably the halogens, in a liquid solvent medium with carbon monoxide at elevated temperature and pressure in the presence of a catalytic amount of a metal carbonyl compound and an alkali or an alkaline earth metal inorganic base.