Di-N.sup.6', O.sup.3 -Demethylistamycin A preparation
US4474946A · kind A · utility
1Cited by
8References
1Claims
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Key dates
| Filing date | Sep 7, 1983 |
| Grant date | Oct 2, 1984 |
| Priority date | — |
| Expiry date | Sep 7, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new istamycin A derivative called di-N.sup.6', O.sup.3 -demethylistamycin A exhibits a high antibacterial activity against various bacteria, particularly Pseudomonas aeruginosa. This compound can be prepared by selective acylation of the methylamino group at the 4-position of 1,2',6'-tri-N-protected N.sup.4 -deglycyl-di-N.sup.6', O.sup.3 -demethylistamycin A with glycine or an N-protected derivative thereof, followed by N-deprotection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.