Nucleophilic substitution process
US4476315A · kind A · utility
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29Claims
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Key dates
| Filing date | Dec 23, 1982 |
| Grant date | Oct 9, 1984 |
| Priority date | — |
| Expiry date | Dec 23, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C253/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their esters are useful intermediates for the synthesis of pharmaceuticals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.