Cephalosporin derivatives and use as antimicrobial agents
US4477448A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1982 |
| Grant date | Oct 16, 1984 |
| Priority date | — |
| Expiry date | Jun 21, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds of formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl, phenylalkyl, carbalkoxyalkyl, acyl, carboxyalkyl, alkoxyalkyl, hydroxyalkyl, cyanoalkyl, or carbamoylalkyl, PA1 R.sub.2 is hydrogen, pivaloyloxymethyl or the residue of an easily splittable ester grouping, PA1 R.sub.3 is a pyrazolyl radical, unsubstituted or mono- or di-substituted by alkyl, phenyl, alkoxy, alkylthio, carboxy, carboxyalkyl, carbamoyl, carbamoylalkyl, alkylsulphonyl, azido, acylamino, hydrazino, acylhydrazino alkylidenehydrazino, phenylidenehydrazino, in which the phenyl nucleus is unsubstituted or substituted by NH.sub.2, lower alkoxy or lower alkyl, furylidenehydrazino, carbalkoxy or a group R.sub.5 R.sub.6 N--, in which R.sub.5 and R.sub.6 are the same or different and are hydrogen or alkyl, provided that the nitrogen atoms and the 4-position of the pyrazole nucleus are either unsubstituted or substituted by alkyl, phenyl, or carbalkoxy, and PA1 R.sub.4 is hydrogen, acetoxy, carbamoyloxy or --S--Rh, in which Rh is a heterocyclic radical.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.