Electrochemical sensing apparatus with in situ calibration
US4478222A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 10, 1981 |
| Grant date | Oct 23, 1984 |
| Priority date | — |
| Expiry date | Mar 10, 2001 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/4165
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An in vivo electrochemical monitoring device is formed by a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. An electrochemical sensor, such as an ISFET device for monitoring the concentration of a particular ion in blood, is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. an infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening. A method of constructing a suitable chamber on an ISFET wafer is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.