Trisubstituted pyrimido[5,4-d]pyrimidines and salts thereof

US4478833A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Josef Roch · Biberach, DE
• Erich Muller · Zell am Harmersbach, DE
• Berthold Narr · Biberach, DE
• Josef Nickl
• Walter Haarmann
• Johannes Weisenberger · Biberach, DE

Key dates

• Filing date: Dec 16, 1981
• Grant date: Oct 23, 1984
• Expiry date: Dec 16, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted alkyl; PA0 R.sub.2 is hydrogen or optionally substituted alkyl; or PA0 R.sub.1 and R.sub.2, together with each other and the nitrogen atom to which they are attached, form an optionally substituted cyclic imino group; PA0 R.sub.3 is an optionally substituted cyclic imino group; and PA0 R.sub.4 is substituted hydroxyl, mercapto or amino; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics.