Aroylaminoacid disulfides
US4479950A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1982 |
| Grant date | Oct 30, 1984 |
| Priority date | — |
| Expiry date | Nov 5, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C327/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the structure ##STR1## wherein: P and Q are independently hydrogen, halo, CF.sub.3, OR.sub.1, SR.sub.1, sulfamoyl, alkyl and NR.sub.1 R.sub.2 ; PA1 R.sub.1, and R.sub.2 are independently hydrogen, alkyl, aminoalky, aryl, aralkyl, heteroaryl or cycloalkyl; PA1 Y is OH, OR.sub.1, NH.sub.2, or, N(R.sub.1 R.sub.2); and PA1 M is alkyl, cycloalkyl, aryl, aminoalkyl, aralkyl, heteroaryl or heterocyclic wherein: PA1 the alkyl groups and the alkyl moieties of aminoalkyl, alkoxy and thioalkyl contain from 1 to 6 carbon atoms; the cycloalkyl group contains from 3 to 8 carbon atoms; the aryl group contains from 6 to 10 carbon atoms; the aralkyl group contains from 7 to 16 carbon atoms; and the hetero group is selected from pyrrolidyl, piperidinyl, morpholinyl, pyridyl, quinolinyl, furyl, furfuryl and thienyl; and where Y is a hydroxy, their pharmaceutically acceptable, non-toxic alkali, alkaline earth and amine salts, have angiotensin converting enzyme inhibitory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.