Indazoloxypropanolamine derivatives and use in combating, and for the prophylaxis of, cardiac and circulatory diseases

US4479962A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Fritz Wiedemann · Weinheim, DE
• Helmut Michel · Mannheim, DE
• Wolfgang Weckerle · Grünstadt, DE
• Egon Roesch · Mannheim, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Aug 2, 1982
• Grant date: Oct 30, 1984
• Expiry date: Aug 2, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides heteroaryloxypropanolamines and pharmaceutical compositions containing them, for combating, and for the prophylaxis of, cardiac and circulatory diseases. The heteroaryloxypropanolamines of the present invention are of the general formula: ##STR1## wherein A is a bi- or tricyclic heteroaromatic radical, which is optionally partly hydrogenated, X is a straight-chained or branched alkylene chain containing 2 to 6 carbon atoms, R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms or lower alkyl or benzyl radicals, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms or lower alkyl, benzyl, formyl, lower alkanoyl, cyano, hydroxymethyl, lower alkoxycarbonyl or carbamoyl radicals or the divalent substituents sulfur or oxygen and R.sub.6, R.sub.7 and R.sub.8, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, nitro, amino, lower alkylthio or lower alkoxy radicals or R.sub.6 and R.sub.7 together represent an optionally unsaturated trimethylene chain; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these co…