Acid-protease inhibiting peptide derivatives
US4481192A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 12, 1983 |
| Grant date | Nov 6, 1984 |
| Priority date | — |
| Expiry date | Aug 12, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/86
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to peptide derivatives of the general formula: EQU R--X--Y--Statyl.sub.1 --Ala--Statyl.sub.2 --R' (1), in which: PA1 Statyl.sub.1 and Statyl.sub.2 represent the radical derived from the aminoacid statine, PA1 R denotes a hydrogen atom or an acylating group attached to the terminal amino group of the aminoacid X--, PA1 X and Y, which are identical or different, denote aminoacids of the L or D configuration if a center of asymmetry exists in the molecule, and optionally protected in their side chain, with the proviso that X and Y cannot simultaneously denote valine, and PA1 R' denotes OH, O-lower alkyl, NH.sub.2 or a group NH-R.sub.1, in which R.sub.1 represents a lower alkyl or lower aralkyl group. It also relates to a process for the preparation of the products of the formula (1) and to the medicaments containing a product of the formula (1) as the active principle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.