E-Homo-eburnane derivatives, process for their preparation, and pharmaceutical compositions containing these compounds
US4481204A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 1983 |
| Grant date | Nov 6, 1984 |
| Priority date | — |
| Expiry date | Jun 29, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to racemic or optically active E-homo-eburnane derivatives of the formula /I/, ##STR1## wherein R.sup.1 and R.sup.2 independently represent an alkyl group having 1 to 6 carbon atoms, PA0 and acid addition salts thereof. The new compounds are pharmaceutically active, for example their certain representatives, in particular from the cis-series, show antidepressive activity, while others, especially the compounds of the trans-series, are potent anthypoxial agents. The compounds of the formula /I/ and pharmaceutically acceptable acid addition salts thereof can therefore be employed as active ingredients of pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.