Process for preparing optically active tryptophanes
US4481362A · kind A · utility
12Cited by
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9Claims
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Key dates
| Filing date | May 17, 1983 |
| Grant date | Nov 6, 1984 |
| Priority date | — |
| Expiry date | May 17, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/227
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.