Therapeutically effective piperidyl N-(4-quinolyl)-anthraniloyloxyalkanoates
US4482561A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1982 |
| Grant date | Nov 13, 1984 |
| Priority date | — |
| Expiry date | Nov 12, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to 4 carbon atoms; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a benzyl, phenethyl, 4-nitrophenethyl or 4-aminophenethyl radical; or a phenacyl, benzoylethyl, .beta.-hydroxyphenethyl or .alpha.-hydroxyphenylpropyl radical, optionally substituted on the phenyl ring by one or more halogen atom, trifluoromethyl, nitro or amino substituents, or an alkyl substituent having from 1 to 4 carbon atoms or an alkoxy substituent having from 1 to 4 carbon atoms; R.sub.1 is a hydrogen atom or a phenyl radical; each of R.sub.2 and R.sub.3 is independently a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; one of R.sub.4 and R.sub.5 is a chlorine atom or a trifluoromethyl radical and the other of R.sub.4 and R.sub.5 is a hydrogen atom; and the pharmaceutically acceptable salts of such esters; are effective analgesics, anti-inflammatories and antidepressants; are also strong inhibitors of platelet aggregation, and thus too …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.