Synthetic analogues of .alpha.-melanotropin
US4485039A · kind A · utility
24Cited by
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8Claims
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Key dates
| Filing date | Jun 11, 1982 |
| Grant date | Nov 27, 1984 |
| Priority date | — |
| Expiry date | Jun 11, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/29
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyclic analogues of the tridecapeptide hormone, .alpha.-melanotropin. (.alpha.-melanocyte stimulating hormone, .alpha.-MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino acid residue at position 10 or 11, and/or (2) between the amino acid residue at position 5 and an amino acid residue at position 10 or 11. Preferred analogues, e.g., [half-Cys.sup.4, half-Cys.sup.10 ]-.alpha.-MSH display greatly increased in vitro potency, prolongation, and resistance to enzymatic degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.