Synthetic phosphatidyl cholines useful in forming liposomes
US4485045A · kind A · utility
609Cited by
6References
5Claims
0Family size
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Inventor
Key dates
| Filing date | May 26, 1982 |
| Grant date | Nov 27, 1984 |
| Priority date | — |
| Expiry date | May 26, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31913
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.