Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4485054A · kind A · utility
232Cited by
9References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 4, 1982 |
| Grant date | Nov 27, 1984 |
| Priority date | — |
| Expiry date | Oct 4, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed on inert, solid contact masses within a vessel, by evaporating an organic solvent therefrom. Subsequent agitation in the presence of an aqueous liquid, followed by a period in which the vessel remains undisturbed yields the multilamellar vesicles. The procedure permits the encapsulation of both hydrophilic and lipophilic materials.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.