Urea-linked immunogens, antibodies, and preparative method
US4486344A · kind A · utility
11Cited by
4References
9Claims
0Family size
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Key dates
| Filing date | Mar 28, 1983 |
| Grant date | Dec 4, 1984 |
| Priority date | — |
| Expiry date | Mar 28, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Immunogen conjugates comprising amino-functionalized haptens coupled through a carbonyl bridge to amino groups in immunogenic proteins and polypeptides. The resulting simple urea linkage in the conjugate is hydrophilic and contributes essentially no haptenic determinants. The immunogen is characterized by a high epitopic density. The method involves reaction of the hapten with a carbonyl diimidazole followed by addition of the protein or polypeptide carrier. Protein crosslinking problems common to prior art coupling methods are avoided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.