Anti-allergy bicyclic phenol ethers

US4486442A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Wolfgang Kampe
• Androniki Roesch nee Apostolides · Mannheim, DE
• Wolfgang Schaumann · Heidelberg, DE

Key dates

• Filing date: Feb 25, 1983
• Grant date: Dec 4, 1984
• Expiry date: Feb 25, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides bicyclic phenol ethers of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical, PA1 R.sub.2 is a hydrogen atom or an acyl radical, PA1 X is an oxygen or sulphur atom or an --NH-- group; PA1 Y is a --CO--CHR.sub.3 -- group or a ##STR2## group; R.sub.3 is a hydrogen atom, a lower alkyl radical which can be optionally substituted by an aryl radical, or a cycloalkyl radical containing 3 to 7 carbon atoms; and PA1 R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms, lower alkyl radicals, lower alkyl radicals, alkenyl radicals containing 2 to 16 carbon atoms, which can be optionally substituted by an aryl radical, or an aryl radical; or PA1 R.sub.4 and R.sub.5, together with the carbon atom to which they are attached, form a cycloalkyl ring containing 3 to 7 carbon atoms; and the PA1 salts thereof with pharmacologically acceptable acids. The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.