Method of conjugating oligopeptides

US4487715A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Danute E. Nitecki · Berkeley, US
• Pradip Kumar Bhatnagar · Exton, US

Key dates

• Filing date: Jul 9, 1982
• Grant date: Dec 11, 1984
• Expiry date: Jul 9, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Novel methods are provided for preparing peptide compounds involving functionalizing an available amino group with a carboxy group, esterifying the carboxy group with an hydroxylic compound which forms an ester which is stable under the conditions of cleavage of the oligopeptide from said resin, but which ester is capable of forming a peptide bond with an amino group in an aqueous medium, and without separation, either allowing the oligopeptide to react with itself or with a polypeptide compound.