Method of preparing 23-monoesters of OMT and DMT
US4487923A · kind A · utility
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Key dates
| Filing date | Mar 14, 1983 |
| Grant date | Dec 11, 1984 |
| Priority date | — |
| Expiry date | Mar 14, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved method of preparing 23-monoester derivatives of 5-O-mycaminosyl tylonolide (OMT) and demycinosyltylosin (DMT) is provided. This method comprises esterifying the antibiotic with an acylating agent in the presence of an external base, such as pyridine or 2,4,6-collidine, until acylation of the 23-hydroxyl group is substantially complete, and separating the 23-monoester derivative. 23-Monoester derivatives of OMT and DMT are useful antibiotics and/or intermediates to antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.