Metorphamide--a novel morphine-like peptide

US4490363A · kind A · utility

Assignee

• Board of Trustees of the Leland Stanford Junior University (A/K/A Stanford University) · US

Inventors

• Jack D. Barchas · Stanford, US
• Eckard Weber · San Diego, US
• Christopher J. Evans · Higganum, US

Key dates

• Filing date: Jun 24, 1983
• Grant date: Dec 25, 1984
• Expiry date: Jun 24, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH.sub.2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high .mu.-binding activity.