N-Desmethyl-N-(allyloxymethyl)-vinblastine and antileukemic and antilymphomic compositions and method of treatment
US4490378A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1983 |
| Grant date | Dec 25, 1984 |
| Priority date | — |
| Expiry date | Jun 13, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl and PA1 R.sup.3 is .alpha.-ethyl; or PA1 R.sup.4 is hydrogen and PA1 R.sup.3 is .beta.-ethyl; PA1 R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety; PA1 R.sup.1 is methoxy and PA1 R.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl, PA1 R.sup.4 is other than ethyl. These compounds and N-desmethyl-N-(ethoxymethyl)-vinblastine can be prepared according to the invention by transetherification of compounds of the compounds of the general formula ##STR2## with a large excess of alcohols of the general formula EQU R"--OH [III] Pharmaceutical compositions containing compounds of the general f…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.