Amidine compound and anticomplement agent comprising same
US4490388A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 1982 |
| Grant date | Dec 25, 1984 |
| Priority date | — |
| Expiry date | Feb 22, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II) EQU R.sub.1 --COOH (II) with 4-(.beta.-amidinoethenyl)phenol represented by the formula (III) ##STR2## and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.