Therapeutically useful imidazo[1,2-a]pyridine derivatives

US4492695A · kind A · utility

Assignee

• Synthelabo · FR

Inventors

• Jean-Pierre Kaplan · Bourg-la-Reine, FR
• Pascal George · Rambouillet, FR
• Jean-Michel Bernardon · Le Rouret, FR

Key dates

• Filing date: Apr 13, 1983
• Grant date: Jan 8, 1985
• Expiry date: Apr 13, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An imidazo[1,2-a]pyridine derivative of the formula: ##STR1## wherein Y represents a hydrogen or halogen atom or a C.sub.1-4 alkyl radical, Z represents a furan-2-yl, thien-2-yl or pyridin-2-yl radical optionally carrying a halogen atom or a methyl or ethyl radical in the 5-position, and R represents the hydroxy radical, a C.sub.1-4 alkoxy radical or a group --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 independently of one another each represent a hydrogen atom; a straight- or branched-chain C.sub.1-5 alkyl radical optionally carrying one or more halogen atoms or a hydroxy radical, a group --N(C.sub.1-4 alkyl).sub.2, a carbamoyl radical or a C.sub.1-4 alkoxy radical; the allyl radical; the propargyl radical; a C.sub.3-6 cycloalkyl radical; the benzyl radical; or the phenyl radical, or alternatively --NR.sub.1 R.sub.2 together represent a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula ##STR2## in which X is O, S, CHOR' or N-R", R' being a hydrogen atom or the benzyl radical and R" being a hydrogen atom, a C.sub.1-4 alkyl radical or the phenyl radical optionally carrying a methoxy radical or a halogen atom, are new compounds. They are …