4-(2-Substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters active on blood circulation

US4492703A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Horst Boshagen · Haan, DE
• Jurgen Stoltefuss · Haan, DE
• Matthias Schramm · Cologne, DE
• Gunter Thomas · Arese, IT
• Stanislav Kazda · Wuppertal, DE

Key dates

• Filing date: Feb 22, 1983
• Grant date: Jan 8, 1985
• Expiry date: Feb 22, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals, PA0 R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S or SO, and PA0 B is a direct bond or alkylene, or pharmaceutically acceptable addition salts thereof exhibit hypotensive, vasodilating and coronary activities.