Process for preparing arylalkylpyruvic acids
US4492798A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 13, 1983 |
| Grant date | Jan 8, 1985 |
| Priority date | — |
| Expiry date | Jan 13, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the production of an arylalkylpyruvic acid of the general formula: EQU (R).sub.n --A--(CH.sub.2).sub.m CH.sub.2 COCOOH wherein: PA1 A represents an aromatic hydrocarbon radical containing 1 or 2 condensed benzene rings, PA1 each R, which may be the same or different, represents hydrogen or a linear or branched alkyl radical with up to 4 carbon atoms which is unsubstituted or substituted by a nitro group or by an alkoxy group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 4 carbon atoms, or a halogeno, nitrile, nitro or alkylcarbonyloxy group, PA1 n is 0 or an integer from 1-3 when A contains one benzene ring, and n is 0 or an integer from 1-5 when A contains two condensed benzene rings and m is 1-20, which comprises carbonylating an arylalkyl halide of the general formula: EQU (R).sub.n --A--(CH.sub.2).sub.m CH.sub.2 X where R, n, A and m are defined above and X represents halogen, by reacting the arylalkyl halide in a liquid solvent medium, with carbon monoxide at elevated temperature and pressure in the presence of a catalytic amount of a metal carbonyl compound and an alkali or an alkaline earth metal inorganic base.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.