Process for preparing a trifluoromethylbenzene derivative
US4493800A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1983 |
| Grant date | Jan 15, 1985 |
| Priority date | — |
| Expiry date | Jun 21, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C253/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a trifluoromethylbenzonitrile derivative of the formula: ##STR1## wherein X is hydrogen, lower alkyl, halogenated lower alkyl, lower alkoxy, nitro, hydroxyl, amino, cyano, carboxyl or sulfon which comprises reacting trifluoromethylhalogenobenzene of the formula: ##STR2## wherein X is as defined above, and Y is halogen with copper (I) cyanide in a solvent selected from the group consisting of hexamethylphosphoric triamide, N-methylpyrrolidone and a mixture thereof in the presence of a catalyst selected from the group consisting of (A) bromine, (B) iodine, (C) a combination of bromine or iodine and metallic copper and (D) copper (II) bromide, by which process the compound (I) is prepared in a good yield, and by-products are produced in a lower yield than the conventional processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.