Determination of oxidized .alpha.-1-proteinase inhibitor in serum or plasma
US4493891A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 27, 1982 |
| Grant date | Jan 15, 1985 |
| Priority date | — |
| Expiry date | Jul 27, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/37
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A new method of determining oxidized .alpha.-1-proteinase inhibitor in serum or plasma for use in studying the development of chronic obstructive lung disease is disclosed. Levels of oxidized .alpha.-1-proteinase inhibitor indicate the potential for emphysema development with higher levels showing a decrease in lung protection against elastolytic enzymes such as elastase. This method can be used for patients with a potential for chronic obstructive lung disease rather than having to use bronchial lavage methods for such patients. No other method is known to exist for determining oxidized .alpha.-1-proteinase inhibitor in serum or plasma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.