Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
US4495281A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1982 |
| Grant date | Jan 22, 1985 |
| Priority date | — |
| Expiry date | Oct 21, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/806
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining such drug. The immunogens comprise the drug coupled at its 2'-position to an immunogenic carrier material. Similarly, the labeled conjugates and synthetic intermediates are 2'-derivatives of the drug or a precursor thereof. The antibodies and labeled reagents are particularly useful in certain homogeneous nonradioisotopic immunoassays for measuring tricyclic antidepressant drugs in biological fluids such as serum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.