N-substituted-amido-amino acids

US4496542A · kind A · utility

Assignee

• USV Pharmaceutical Corporation · US

Inventors

• Jerry W. Skiles · Tuckahoe, US
• Raymond D. Youssefyeh · Tarrytown, US
• John T. Suh · Greenwich, US
• Howard Jones · Holmdel, US

Key dates

• Filing date: Apr 13, 1983
• Grant date: Jan 29, 1985
• Expiry date: Apr 13, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R and R.sub.9 are independently hydroxy and lower alkoxy, PA1 R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms, PA1 R.sub.3, R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are hydrogen or lower alkyl, PA1 R.sub.6 is heterocyclic and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R.sub.9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts, possess antihypertensive activity.