Benzo-fused thromboxane synthetase inhibitors
US4496572A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 9, 1982 |
| Grant date | Jan 29, 1985 |
| Priority date | — |
| Expiry date | Aug 9, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel series of carboxy-substituted naphthalenes and carboxy-substituted benzo-fused heterocycles, such as carboxy-substituted derivatives of indole, benzofuran and benzothiophene, has been prepared, including their pharmaceutically acceptable salts. These particular compounds are useful in therapy for the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, peripheral vascular disease, the vascular complications of diabetes and endotoxic shock. Preferred member compounds include 2-(1-imidazolylmethyl)-3-methylbenzo[b]thiophene-5-carboxylic acid and 3-methyl-2-(3-pyridylmethyl)benzo[b]thiophene-5-carboxylic acid, respectively. Methods for preparing these compounds from known starting materials are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.