Process for the determination of antithrombin-BM

US4496653A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Helmut Lill · Wielenbach, DE
• Jurgen Schrenk · Weilheim, DE
• Peter Wunderwald · Haunshofen, DE

Key dates

• Filing date: Jun 9, 1982
• Grant date: Jan 29, 1985
• Expiry date: Jun 9, 2002

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2400/40
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

For the determination of antithrombin-BM an antithrombin-BM-cofactor, thrombin and a determinable thrombin substrate are added to a sample solution and the splitting of the thrombin substrate is determined as a measure for the antithrombin-BM activity, whereby heparin, xylan, .lambda.-carrageenan, dextran sulphate, mucopolysaccharide polysulphuric acid esters, pentosan polysulphates or short-chained heparin derivatives produced by the chemical or enzymatic splitting of heparin are used as cofactors.