11.alpha.-amino-androstanes
US4497805A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1983 |
| Grant date | Feb 5, 1985 |
| Priority date | — |
| Expiry date | Mar 16, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 is a C.sub.1-8 alkyl group or a C.sub.3-7 cycloalkyl group; PA1 R.sup.2 is a C.sub.1-6 alkyl group or a C.sub.3-7 cycloalkyl group; PA1 R.sup.3 is a hydroxy group or a group of formula --OR.sup.4 or --OCOR.sup.5 where PA1 R.sup.4 is an alkyl or alkenyl group which may contain up to 6 carbon atoms (or such a group substituted by halogen, C.sub.1-6 alkoxy, carboxyl, phenyl, phenyl substituted by nitro, halo, C.sub.1-4 alkoxy or C.sub.1-4 alkyl), a C.sub.3-7 cycloalkyl group, a phenyl group (or such a group substituted by nitro, halo, C.sub.1-4 alkoxy or C.sub.1-4 alkyl), or a carbon-attached 5-7 membered heterocyclic ring in which the hetero atom is selected from nitrogen, oxygen and sulphur, and PA1 R.sup.5 is a hydrogen atom or a group R.sup.4 as defined above; and the D-homo analogues thereof having the group --CO.sub.2 R.sup.2 (wherein R.sup.2 is as defined above) at the 17a.beta.-position, and salts thereof have activity as antidysrhythmic agents and may be applicable for the treatment of dysrhthmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers or excipi…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.