2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and platelet aggregation inhibitors

US4497818A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Arthur F. Kluge · Lincoln, US
• Arthur M. Strosberg · Menlo Park, US
• Roger Whiting · Los Altos, US
• George A. Christie · Edinburgh, GB

Key dates

• Filing date: Aug 5, 1981
• Grant date: Feb 5, 1985
• Expiry date: Aug 5, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, and alkyl (1-6C), and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are .alpha..sub.2 blockers and thus are useful as affectors of the CNS, specifically as platelet aggregation inhibitors and as antihypertensives.