Medicaments having antihypoxic and ischaemia-protective activity

US4497821A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Egbert Wehinger
• Horst Meyer
• Ulrich Benz · Goldkronach, DE

Key dates

• Filing date: Feb 28, 1983
• Grant date: Feb 5, 1985
• Expiry date: Feb 28, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of controlling damage to the central nervous system of a patient which comprises administering to such patient a central nervous system-controlling effective amount of a pyridine derivative of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical, PA1 R.sup.1 and R.sup.2 are hydrogen or various organic radicals, PA1 X and Y are CN, --CO--R.sup.3, --COOR.sup.4 or --SO.sub.2 R.sup.5, or form with R.sup.1 or R.sup.2 a carbonyl-containing ring, PA1 R.sup.3 is an alkyl, aryl or aralkyl radical, PA1 R.sup.4 is hydrogen or an organic radical, and PA1 R.sup.5 is an optionally substituted alkyl or phenyl radical, or a salt thereof.