Process for preparing optically active tryptophans
US4497957A · kind A · utility
8Cited by
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11Claims
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Key dates
| Filing date | Jun 25, 1982 |
| Grant date | Feb 5, 1985 |
| Priority date | — |
| Expiry date | Jun 25, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/227
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Biochemical optical resolution of DL-tryptophans in which DL-tryptophan amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-Tryptophan amides in racemic DL-tryptophan amides are asymmetrically hydrolyzed to form optically active L-tryptophans at a high yield and almost all D-tryptophan amides remain without being subjected to hydrolysis. The resultant D-tryptophan amides are readily hydrolyzed, after separating L-tryptophans, to form optically active D-tryptophans at a high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.